Natural killer cells, T- and B-cells, monocytes/ macrophages, dendritic cells.
Intestinal epithelial cells, B-cell subsets, cortical thymocytes, dendritic cells and certain T-cell leukemias. 1Ĭortical thymocytes, Langerhans cells, dendritic cells and B-cell subsets. Non-peptide antigen presentation to T-cell receptors on NKT cells. 1Ĭortical thymocytes, Langerhans cells and dendritic cells. Mediates the presentation of lipid and glycolipid antigens to T-cells. Select a target name to find related products.ĭownload your human CD antigen guide pdf.Ĭortical thymocytes, Langerhans cells, dendritic cells and certain T-cell leukemias. Use the table below to find your target of interest, with corresponding information from relevant scientific literature and the Human Cell Differentiation Molecules (HCDM) organization. Monitoring the expression profiles of different CD antigens has permitted the identification, isolation and phenotyping of cell types according to their function in various immune processes. Varying cellular expression levels are also marked as hi or low, for example central memory T-cells are CD62Lhi whereas effector memory T-cells are CD62Llow. The presence or absence of a specific antigen from the surface of a particular cell population is denoted with “+” or “-" respectively. As of April 2016, h uman CD antigens are numbered up to CD371. Although initially used just for human leukocytes, the CD molecule naming convention has now been expanded to cover different species (eg mouse) as well as other cell types. Physiologically, CD molecules do not belong in any particular class, with their functions ranging widely from cell surface receptors to adhesion molecules. Lower class letters are also added after the assigned number to indicate larger molecules that share a common chain, for example CD1a or CD1d. Under this naming system, antigens that are well characterized are assigned an arbitrary number (eg CD1, CD2 etc) whereas molecules that are recognized by just one monoclonal antibody are given the provisional designation “CDw” eg CDw50. The Human Cell Differentiation Molecules organization continues to hold HLDA conferences to maintain and develop the list of known CD markers. The current system was adopted in 1982 through the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA). As there were often multiple monoclonal antibodies raised against each antigen in different labs, the need arose to adopt a consistent nomenclature.
#HALF LIFE CD KEY 25 DIGITS HOW TO#
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